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KMID : 0390220210320030221
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Journal of Clinical Otolaryngology, Head and Neck Surgery
2021 Volume.32 No. 3 p.221 ~ p.227
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Correlation between Vitamin D Level and Obstructive Sleep Apnea Severity in Korean Children
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Chae Min-Suk
Kim Ji-Sun
Ahn Young-Min
Kim Ho-Chan
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Abstract
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Background and Objectives: To evaluate relationship between vitamin D and severity of obstructive sleep apnea (OSA) in Korean children.
Materials and Methods: This study was conducted on children aged 5 to 17 years who had polysomnography and blood 25-hydroxyvitamin D (25(OH)D) measurements from January 2015 to July 2018 in our Medical Center. Apnea hypopnea index (AHI) 1 or higher was considered to be an OSA patient, and obesity was defined when the body mass index (BMI) was 95% or more of each age and gender. Vitamin D level was checked through 25(OH)D in blood.
Results: Of the total 109 children included in the study, the mean blood concentration of 25(OH)D was 19.5±7.1 ng/mL and AHI was 5.4±15.8 /h. Sixty-five children (59.6%) were Vitamin D deficient. In bivariate correlation analysis, 25(OH)D level and BMI z-score (r=?0.24, p=0.01), AHI (r=?0.22, p=0.02) showed a statistically significant negative correlation. Forty children were obese, and the 25(OH)D in the obese group was statistically significantly lower (p=0.08). In the obese group, 25(OH)D was not statistically correlated with AHI, but obstructive portion of AHI obstructive showed a statistically negative correlation (r=?0.36 , p=0.02). Compared to the non-OSA group, the OSA group had a statistically significantly lower 25(OH)D (p=0.04).
Conclusions: Vitamin D level was lower in obese children and children with OSA. There was a correlation between the severity of OSA and vitamin D deficiency.
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KEYWORD
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Vitamin D, Sleep apnea, obstructive, Child, Metabolic syndrome
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